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Article

Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum.

Biochimica et biophysica acta. Molecular basis of disease - 1 Apr 2023

Zhang Jing, Li Jie, You Pan, Jiang Haitian, Liu Yanjun, Han Daobin, Liu Meiqi, Yu Hui, Su Bo

Abstract excerpt

Hyperphosphorylated Rab10 has been implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. However, the neurophysiological function of the evolutionarily conserved Thr73 phosphorylation of Rab10 remains poorly understood. Here, we generated a novel mouse model expressing the non-phosphorylatable T73V mutation of Rab10 and performed a comprehensive series...

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PMID: 36669576
DOI: 10.1016/j.bbadis.2023.166641

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