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Article

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.

The Biochemical journal - 2 Jan 2018

Lis Pawel, Burel Sophie, Steger Martin, Mann Matthias, Brown Fiona, Diez Federico, Tonelli Francesca, Holton Janice L, Ho Philip Winglok, Ho Shu-Leong, Chou Meng-Yun, Polinski Nicole K, Martinez Terina N, Davies Paul, Alessi Dario R

Abstract excerpt

Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose to Parkinson's disease, suggesting that LRRK2 inhibitors might have therapeutic benefit. Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10, at a specific residue located at the centre of its effector-binding switch-II motif. In the present study, we analyse the...

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Source

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Identifiers

PMID: 29127256
DOI: 10.1042/BCJ20170802
PMCID: PMC5748839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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