Article
Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015
Yoon Kyoung-Hye, Ragoczy Tobias, Lu Zhonghua, Kondoh Kunio, Kuang Donghui, Groudine Mark, Buck Linda B
Abstract excerpt
The olfactory system translates a vast array of volatile chemicals into diverse odor perceptions and innate behaviors. Odor detection in the mouse nose is mediated by 1,000 different odorant receptors (ORs) and 14 trace amine-associated receptors (TAARs). ORs are used in a combinatorial manner to encode the unique identities of myriad odorants. However, some TAARs appear to be linked to innate responses, raising...
Topics
- Alleles
- Animals
- Cell Lineage
- Cell Nucleus
- Chromosomes, Artificial, Bacterial
- Crosses, Genetic
- Female
- Gene Expression Regulation
- Heterochromatin
- In Situ Hybridization
- In Situ Hybridization, Fluorescence
- Lamin Type A
- Male