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Article

Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.

PLoS biology - 1 Jan 2013

Fleischmann Alexander, Abdus-Saboor Ishmail, Sayed Atef, Shykind Benjamin

Abstract excerpt

The odorant receptor (OR) genes constitute the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion, through an unknown mechanism that likely exploits positive and negative regulation. We devised a genetic strategy in mice to examine OR selection by determining the transcriptional activity of an exogenous promoter homologously integrated into an OR locus. Using the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23700388
DOI: 10.1371/journal.pbio.1001568
PMCID: PMC3660300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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