Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons.

eNeuro - 1 Jan 2016

Zhang Guangfan, Titlow William B, Biecker Stephanie M, Stromberg Arnold J, McClintock Timothy S

Abstract excerpt

A developmental program of epigenetic repression prepares each mammalian olfactory sensory neuron (OSN) to strongly express one allele from just one of hundreds of odorant receptor (OR) genes, but what completes this process of OR gene choice by driving the expression of this allele is incompletely understood. Conditional deletion experiments in mice demonstrate that Lhx2 is necessary for normal expression...

Topics

Animals
Female
Fluorescent Antibody Technique
Gene Expression Regulation
Homeodomain Proteins
In Situ Hybridization
LIM-Homeodomain Proteins
Male
Mice, Transgenic
Microarray Analysis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Olfactory Receptor Neurons

RNA, Messenger

Receptors, Odorant

Transcription Factors

Empty Spiracles Homeobox Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27822500
DOI: 10.1523/ENEURO.0230-16.2016
PMCID: PMC5086798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons.PMID 27822500Read ↗

Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments.Semantic proximity Read ↗

Prominent roles for odorant receptor coding sequences in allelic exclusion.Semantic proximity Read ↗

Epigenetics. A new whiff of monoallelic expression.Semantic proximity Read ↗

Monogenic and Monoallelic Expression of Odorant Receptors.Semantic proximity Read ↗

Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice.Semantic proximity Read ↗

Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.Semantic proximity Read ↗

Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem.Semantic proximity Read ↗

Regulation of odorant receptors: one allele at a time.Semantic proximity Read ↗

Nuclear architecture and gene silencing in olfactory sensory neurons.Semantic proximity Read ↗

Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.Semantic proximity Read ↗

An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice.Semantic proximity Read ↗

Establishment and maintenance of random monoallelic expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.