Nuclear architecture and gene silencing in olfactory sensory neurons.

doi:10.4161/19490992.2014.982934

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Article

Nuclear architecture and gene silencing in olfactory sensory neurons.

Bioarchitecture - 1 Jan 2014

Armelin-Correa Lucia M, Nagai Maíra H, Leme Silva Artur G, Malnic Bettina

Abstract excerpt

Odorants are discriminated by hundreds of odorant receptor (OR) genes, which are dispersed throughout the mammalian genome. The OR genes are expressed in a highly specialized type of cell, the olfactory sensory neuron. Each one of these neurons expresses one of the 2 alleles from one single OR gene type. The mechanisms underlying OR gene expression are unclear. Here we describe recent work demonstrating that the...

Topics

Alleles
Animals
Cell Nucleus
Gene Expression Regulation
Heterochromatin
Olfactory Receptor Neurons
Receptors, Odorant

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Identifiers

PMID: 25714005
DOI: 10.4161/19490992.2014.982934
PMCID: PMC4914026

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