Article
A biosensor for D-2-hydroxyglutarate in frozen sections and intraoperative assessment of IDH mutation status.
Biosensors & bioelectronics - 1 Mar 2024
Zhang Wen, Yang Mu, Wang Gang, Ou Shaowu, Hu Jinqu, Liu Jiyuan, Lei Yuxin, Kang Zhaoqi, Wang Fang, Liu Jiang, Ma Cuiqing, Wang Chengwei, Gao Chao, Tang Dongqi
Abstract excerpt
The oncometabolite D-2-hydroxyglutarate (D-2-HG) has emerged as a valuable biomarker in tumors with isocitrate dehydrogenase (IDH) mutations. Efficient detection methods are required and rapid intraoperative determination of D-2-HG remains a huge challenge. Herein, D-2-HG dehydrogenase from Achromobacter xylosoxidans (AX-D2HGDH) was found to have high substrate specificity. AX-D2HGDH dehydrogenizes D-2-HG and...
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