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Article

Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate.

Acta neuropathologica - 1 Dec 2012

Balss Jörg, Pusch Stefan, Beck Ann-Christin, Herold-Mende Christel, Krämer Alwin, Thiede Christian, Buckel Wolfgang, Langhans Claus-Dieter, Okun Jürgen G, von Deimling Andreas

Abstract excerpt

Levels of (D)-2-hydroxyglutarate [D2HG, (R)-2-hydroxyglutarate] are increased in some metabolic diseases and in neoplasms with mutations in the isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) genes. Determination of D2HG is of relevance to diagnosis and monitoring of disease. Standard detection methods of D2HG levels are liquid-chromatography-mass spectrometry or gas-chromatography-mass...

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Source

Identifiers

PMID: 23117877
DOI: 10.1007/s00401-012-1060-y

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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