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Article

Single-cell profiling of D-2-hydroxyglutarate using surface-immobilized resazurin analogs.

Biosensors & bioelectronics - 15 Oct 2021

Cheng Hanjun, Li Zhonghan, Guo Zhili, Shao Shiqun, Mo Li, Wei Wei, Xue Min

Abstract excerpt

D-2-hydroxyglutarate (D2HG) is over-produced as an oncometabolite due to mutations in isocitrate dehydrogenases (IDHs). Accumulation of D2HG can cause the dysfunction of many enzymes and genome-wide epigenetic alterations, which can promote oncogenesis. Quantification of D2HG at single-cell resolution can help understand the phenotypic signatures of IDH-mutant cancers and identify effective therapeutics. In this...

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Identifiers

PMID: 34098361
DOI: 10.1016/j.bios.2021.113368
PMCID: PMC8321683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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