Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.

Nature communications - 7 Dec 2021

Xiao Dan, Zhang Wen, Guo Xiaoting, Liu Yidong, Hu Chunxia, Guo Shiting, Kang Zhaoqi, Xu Xianzhi, Ma Cuiqing, Gao Chao, Xu Ping

Abstract excerpt

D-2-Hydroxyglutarate (D-2-HG) is a metabolite involved in many physiological metabolic processes. When D-2-HG is aberrantly accumulated due to mutations in isocitrate dehydrogenase or D-2-HG dehydrogenase, it functions in a pro-oncogenic manner and is thus considered a therapeutic target and biomarker in many cancers. In this study, DhdR from Achromobacter denitrificans NBRC 15125 is identified as an allosteric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases
Share to Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biosensing Techniques

Share to Glutarates

Share to HEK293 Cells

Share to Isocitrate Dehydrogenase

Share to Metabolic Networks and Pathways

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 34876568
DOI: 10.1038/s41467-021-27357-7
PMCID: PMC8651671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.PMID 34876568Read ↗

A fluorescent l-2-hydroxyglutarate biosensorSemantic proximity Read ↗

A biosensor for D-2-hydroxyglutarate in frozen sections and intraoperative assessment of IDH mutation status.Semantic proximity Read ↗

Single-cell profiling of D-2-hydroxyglutarate using surface-immobilized resazurin analogs.Semantic proximity Read ↗

Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic SpeciesSemantic proximity Read ↗

Precise Regulation of Differential Transcriptions of Various Catabolic Genes by OdcR via a Single Nucleotide Mutation in the Promoter Ensures the Safety of Metabolic Flux.Semantic proximity Read ↗

The transcriptome analysis of Escherichia coli responding to telluriteSemantic proximity Read ↗

EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehydeSemantic proximity Read ↗

Glyoxylate reductase as versatile enzymatic system for pharmaceutical and medical useSemantic proximity Read ↗

The Applications of Promoter-Gene Engineered Bio-SensorsSemantic proximity Read ↗

High-Throughput Screening of Coenzyme Preference Change of Thermophilic 6-Phosphogluconate Dehydrogenase from NADP(+) to NAD(.).Semantic proximity Read ↗

Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox Processes with Denaturing Agents.Semantic proximity Read ↗

Dynamic interactive events in gene regulation using E. coli dehydrogenase as a model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.