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Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction.

Diabetologia - 1 Nov 2021

Amirruddin Nur Shabrina, Tan Wei Xuan, Tan Yaw Sing, Gardner Daphne Su-Lyn, Bee Yong Mong, Verma Chandra Shekhar, Hoon Shawn, Lee Kok Onn, Teo Adrian Kee Keong

Abstract excerpt

AIMS/HYPOTHESIS: We studied the effects of heterozygous human INS gene mutations on insulin secretion, endoplasmic reticulum (ER) stress and other mechanisms in both MIN6 and human induced pluripotent stem cells (hiPSC)-derived beta-like cells, as well as the effects of prolonged overexpression of mutant human INS in MIN6 cells. METHODS: We modelled the structure of mutant C109Y and G32V proinsulin...

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PMID: 34448879
DOI: 10.1007/s00125-021-05530-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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