Article

Modeling physiological insulin sensitivity and pre-diabetic insulin resistance in multiple hPSC-derived cell types

2025-10-16

Abstract excerpt

Recently, we demonstrated the development of a human pluripotent stem cell (hPSC)-derived adipocyte (fat cell) model with physiological insulin signaling. For the first time, a human in vitro adipocyte cell model has an insulin response similar to in vivo human adipocytes. We next leveraged this protocol to study the early stages of insulin resistance preceding Type 2 Diabetes, by exposing these cells to diabetic...

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Literature Corpus work: fac68d05-848c-550b-84fa-1e44b8225210
DOI: 10.1101/2025.10.14.682181

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