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Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

25 Oct 2023

Abstract excerpt

Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus...

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PMID: 37880247
DOI: 10.1038/s41467-023-42526-6

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