Article

Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1

2019-08-16

Abstract excerpt

Comprehensive knowledge of the host factors required for picornavirus infection would facilitate antiviral development. Here we demonstrate roles for three human genes, TNK2, WASL, and NCK1, in infection by multiple picornaviruses. CRISPR deletion of TNK2, WASL or NCK1 reduced encephalomyocarditis virus (EMCV), coxsackievirus B3 (CVB3), poliovirus and enterovirus D68 infection, and chemical inhibitors of TNK2 and...

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Literature Corpus work: 9af94e95-7e72-5f30-ba67-31e82d4dbce1
DOI: 10.1101/737635

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