Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activity

13 Dec 2023

Abstract excerpt

Macrophages play a crucial role in shaping the immune state within the tumor microenvironment (TME) and are often influenced by tumors to hinder antitumor immunity. However, the underlying mechanisms are still elusive. Here, we observed abnormal expression of complement 5a receptor (C5aR) in human ovarian cancer (OC), and identified high levels of C5aR expression on tumor-associated macrophages (TAMs), which led...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Immune Cell Function and Interaction
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38098230
DOI: 10.1016/j.ymthe.2023.12.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activityPMID 38098230Read ↗

The complement system as a target in cancer immunotherapySemantic proximity Read ↗

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironmentsSemantic proximity Read ↗

Interplay between the complement system and other immune pathways in the tumor microenvironmentSemantic proximity Read ↗

C3AR1 promotes ovarian cancer progression and induces suppressive immunocyte infiltration: evidence from comprehensive bioinformatics analysis and experimentsSemantic proximity Read ↗

Complement Pathway Is Frequently Altered in Endometriosis and Endometriosis-Associated Ovarian CancerSemantic proximity Read ↗

Inhibition of furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities.Semantic proximity Read ↗

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic OpportunitiesSemantic proximity Read ↗

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical TrialSemantic proximity Read ↗

Non-canonical extracellular complement pathways and the complosome paradigm in cancer: a scoping reviewSemantic proximity Read ↗

Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironmentSemantic proximity Read ↗

Complement activation shapes immune contexture and immunotherapy response in clear cell renal cell carcinomaSemantic proximity Read ↗

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent mannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.