Article

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

2023-01-10

Abstract excerpt

An immunosuppressive microenvironment causes poor tumour T-cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumours is still a challenge. Using an integrated screening approach to identify cancer-specific vulnerabilities, we identify complement receptor C5aR1 as a druggable target which when inhibited improves radiotherapy e...

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Literature Corpus work: 1dd1e2ee-76d6-51b3-82fa-48f6c916e7d3
DOI: 10.1101/2023.01.10.521547

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