Article

Cellular Senescence Impairs Tendon Extracellular Matrix Remodeling in Response to Mechanical Unloading

2023-12-23

Abstract excerpt

Musculoskeletal injuries, including tendinopathies, present a significant clinical burden for aging populations. While the biological drivers of age-related declines in tendon function are poorly understood, it is well accepted that dysregulation of extracellular matrix (ECM) remodeling plays a role in chronic tendon degeneration. Senescent cells, which have been associated with multiple degenerative pathologies i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea6378ef-bec2-5a7f-8cd8-0c282632a17a
DOI: 10.1101/2023.12.22.572594

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular Senescence Impairs Tendon Extracellular Matrix Remodeling in Response to Mechanical UnloadingDOI 10.1101/2023.12.22.572594Read

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseasesSemantic proximity Read

Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function.Semantic proximity Read

Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of Senescence.Semantic proximity Read

Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degenerationSemantic proximity Read

Cellular Senescence in Aging, Tissue Repair, and RegenerationSemantic proximity Read

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironmentSemantic proximity Read

Dynamic regulation of myofibroblast phenotype in cellular senescence.Semantic proximity Read

Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells.Semantic proximity Read

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependentSemantic proximity Read

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritisSemantic proximity Read

Extracellular Vesicle‐Contained Thrombospondin 1 Retards Age‐Related Degenerative Tendinopathy by Rejuvenating Tendon Stem/Progenitor Cell SenescenceSemantic proximity Read

Cellular senescence and other age-related mechanisms in skeletal diseasesSemantic proximity Read