Article
A new antibiotic selectively kills Gram-negative pathogens.
Nature - 1 Dec 2019
Imai Yu, Meyer Kirsten J, Iinishi Akira, Favre-Godal Quentin, Green Robert, Manuse Sylvie, Caboni Mariaelena, Mori Miho, Niles Samantha, Ghiglieri Meghan, Honrao Chandrashekhar, Ma Xiaoyu, Guo Jason J, Makriyannis Alexandros, Linares-Otoya Luis, Böhringer Nils, Wuisan Zerlina G, Kaur Hundeep, Wu Runrun, Mateus André, Typas Athanasios, Savitski Mikhail M, Espinoza Josh L, O'Rourke Aubrie, Nelson Karen E, Hiller Sebastian, Noinaj Nicholas, Schäberle Till F, D'Onofrio Anthony, Lewis Kim
Abstract excerpt
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative bacteria was developed in the 1960s2. We reason that useful compounds can be found in bacteria that share similar...
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