Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

13 Dec 2023

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38092857
DOI: 10.1038/s41551-023-01157-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repairPMID 38092857Read ↗

Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cellsSemantic proximity Read ↗

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell typesSemantic proximity Read ↗

Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavageSemantic proximity Read ↗

A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cellsSemantic proximity Read ↗

Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cellsSemantic proximity Read ↗

Cas9‐Cleavage Sequences in Size‐Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T CellsSemantic proximity Read ↗

Ultra-large targeted DNA integrations in primary human cellsSemantic proximity Read ↗

Engineering Tripartite Gene Editing Machinery for Highly Efficient Non-Viral Targeted Genome IntegrationSemantic proximity Read ↗

Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cellsSemantic proximity Read ↗

Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cellsSemantic proximity Read ↗

Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cellsSemantic proximity Read ↗

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.