Article
Sequence-Guided Localization of DNA Hybridization Enables Highly Selective and Robust Genotyping.
Small (Weinheim an der Bergstrasse, Germany) - 1 May 2024
Wang Xuchu, Chen Tao, Ping Ying, Dai Yibei, Yu Pan, Xie Yiyi, Liu Zhenping, Sun Bohao, Duan Xiuzhi, Tao Zhihua
Abstract excerpt
Genetic variations are always related to human diseases or susceptibility to therapies. Nucleic acid probes that precisely distinguish closely related sequences become an indispensable requisite both in research and clinical applications. Here, a Sequence-guided DNA LOCalization for leaKless DNA detection (SeqLOCK) is introduced as a technique for DNA hybridization, where the intended targets carrying distinct...
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