Article
Robust electrochemical system for screening single nucleotide polymorphisms.
Chemical communications (Cambridge, England) - 28 Jan 2011
Hu Rong, Wu Zai-Sheng, Zhang Songbai, Shen Guo-Li, Yu Ruqin
Abstract excerpt
A highly sensitive and selective electrochemical DNA signaling scheme, which identifies the point mutation existing in target DNA sequence, is developed based on the combination of label-free hairpin probe (HP)/DNA endonuclease with zirconia (ZrO(2)) nanoparticle film, representing a promising screening platform for the accurate diagnosis of infections and genetic diseases as well as for environmental and...
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