Article
Logical Analysis of Multiple Single-Nucleotide-Polymorphisms with Programmable DNA Molecular Computation for Clinical Diagnostics.
Angewandte Chemie (International ed. in English) - 4 Apr 2022
Zhang Chao, Zheng Tingting, Ma Qian, Yang Linlin, Zhang Mingzhi, Wang Junyan, Teng Xiaoyan, Miao Yanyan, Lin Hsiao-Chu, Yang Yang, Han Da
Abstract excerpt
Analyzing complex single-nucleotide-polymorphism (SNP) combinations in the genome is important for research and clinical applications, given that different SNP combinations can generate different phenotypic consequences. Recent works have shown that DNA-based molecular computing is powerful for simultaneously sensing and analyzing complex molecular information. Here, we designed a switching circuit-based DNA...
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