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Article

The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma.

Journal of translational medicine - 11 Dec 2023

Yao Shifei, Weng Danlin, Wang Yan, Zhang Yanyu, Huang Qi, Wu Kaifeng, Li Honghui, Zhang Xuemei, Yin Yibing, Xu Wenchun

Abstract excerpt

BACKGROUND: Early microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely determined. METHODS: BALB/c mice were pretreated with the PepN protein...

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Identifiers

PMID: 38082290
DOI: 10.1186/s12967-023-04768-2
PMCID: PMC10712085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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