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Article

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice.

The Journal of clinical investigation - 1 Jun 2012

Mahdi Layla K, Wang Hui, Van der Hoek Mark B, Paton James C, Ogunniyi Abiodun D

Abstract excerpt

Streptococcus pneumoniae is the most common cause of severe bacterial meningitis in children, the elderly, and immunocompromised individuals. To identify virulence factors preferentially expressed during meningitis, we conducted niche-specific genome-wide in vivo transcriptomic analysis after intranasal infection of mice with serotype 4 or 6A pneumococci. The expression of 34 bacterial genes was substantially...

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Source

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Identifiers

PMID: 22622042
DOI: 10.1172/JCI45850
PMCID: PMC3366392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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