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Article

Pneumococcal Extracellular Vesicles Modulate Host Immunity.

mBio - 31 Aug 2021

Yerneni Saigopalakrishna S, Werner Sarah, Azambuja Juliana H, Ludwig Nils, Eutsey Rory, Aggarwal Surya D, Lucas Peter C, Bailey Nathanael, Whiteside Theresa L, Campbell Phil G, Hiller N Luisa

Abstract excerpt

Extracellular vesicles (EVs) have recently garnered attention for their participation in host-microbe interactions in pneumococcal infections. However, the effect of EVs on the host immune system remain poorly understood. Our studies focus on EVs produced by Streptococcus pneumoniae (pEVs), and reveal that pEVs are internalized by macrophages, T cells, and epithelial cells. In vitro, pEVs induce NF-κB activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34253061
DOI: 10.1128/mBio.01657-21
PMCID: PMC8406339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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