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Uncovering the Neuroprotective Effect of Vitamin B12 in Pneumococcal Meningitis: Insights into Its Pleiotropic Mode of Action at the Transcriptional Level

2023-06-15

Abstract excerpt

<h4>Background: </h4> The interplay between bacterial virulence factors and the host innate immune response in pneumococcal meningitis (PM) can result in uncontrolled neuroinflammation, which is known to induce apoptotic death of progenitor cells and post-mitotic neurons in the hippocampal dentate gyrus, resulting in cognitive impairment. Vitamin B12 attenuates hippocampal damage and reduces the expression of some...

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Literature Corpus work
295b469d-5160-5584-ad44-70f7423a034b
DOI
10.21203/rs.3.rs-3055265/v1
Open publication

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Uncovering the Neuroprotective Effect of Vitamin B12 in Pneumococcal Meningitis: Insights into Its Pleiotropic Mode of Action at the Transcriptional LevelDOI 10.21203/rs.3.rs-3055265/v1
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