Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition

11 Dec 2023

Abstract excerpt

Abstract The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein complexes encompassing tumor neoantigens provide a rationale for target selection towards autologous T cell, vaccine, and antibody-based therapeutic modalities. Here, using complementary biophysical and computational methods, we characterize recurrent RAS55-64Q61 neoepitopes presented by the common HLA-A*01:01 allotype. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38081856
DOI: 10.1038/s41467-023-43654-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognitionPMID 38081856Read ↗

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigensSemantic proximity Read ↗

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigensSemantic proximity Read ↗

A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.Semantic proximity Read ↗

Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansionSemantic proximity Read ↗

A biophysical framework for accurately identifying antigen single-amino acid escape variants and corresponding variant-specific compensatory TCR sequencesSemantic proximity Read ↗

A generalizable system for antigenic peptide targeting across HLA-I allotypesSemantic proximity Read ↗

Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry.Semantic proximity Read ↗

Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicitySemantic proximity Read ↗

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01Semantic proximity Read ↗

CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorderSemantic proximity Read ↗

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens.Semantic proximity Read ↗

Structure-based modeling of SARS-CoV-2 peptide/HLA-A02 antigensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.