Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

21 Feb 2019

Abstract excerpt

Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2.4 Å resolution map of the binding interface...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30792391
DOI: 10.1038/s41467-019-08790-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01PMID 30792391Read ↗

High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes.Semantic proximity Read ↗

Topographic map of the HLA-A2 CREG epitopes using human alloantibody probesSemantic proximity Read ↗

Structural and electrostatic analysis of HLA B-cell epitopesSemantic proximity Read ↗

The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.Semantic proximity Read ↗

Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognitionSemantic proximity Read ↗

Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11Semantic proximity Read ↗

Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptorSemantic proximity Read ↗

Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors.Semantic proximity Read ↗

16th IHIW: a website for antibody-defined HLA epitope Registry.Semantic proximity Read ↗

Broadening alloselectivity of T cell receptors by structure guided engineering.Semantic proximity Read ↗

The HLA system: immunobiology, HLA typing, antibody screening and crossmatching techniquesSemantic proximity Read ↗

Antibody-reactive epitope determination with HLAMatchmaker and its clinical applications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.