Article
A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.
Frontiers in immunology - 1 Jan 2018
Toor Jugmohit S, Rao Arjun A, McShan Andrew C, Yarmarkovich Mark, Nerli Santrupti, Yamaguchi Karissa, Madejska Ada A, Nguyen Son, Tripathi Sarvind, Maris John M, Salama Sofie R, Haussler David, Sgourakis Nikolaos G
Abstract excerpt
The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequencing data from neuroblastoma patients and identify a recurrent anaplastic lymphoma kinase...
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