Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial Transcriptome‐Wide Profiling of Small Cell Lung Cancer Reveals Intra‐Tumoral Molecular and Subtype Heterogeneity

19 Jun 2024

Abstract excerpt

Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid growth and early metastasis and is susceptible to treatment resistance and recurrence. Understanding the intra-tumoral spatial heterogeneity in SCLC is crucial for improving patient outcomes and clinically relevant subtyping. In this study, a spatial whole transcriptome-wide analysis of 25 SCLC patients at sub-histological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38896789
DOI: 10.1002/advs.202402716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial Transcriptome‐Wide Profiling of Small Cell Lung Cancer Reveals Intra‐Tumoral Molecular and Subtype HeterogeneityPMID 38896789Read ↗

Spatially Preserved Multi-Region Transcriptomic Subtyping and Biomarkers of Chemoimmunotherapy Outcome in Extensive-Stage Small Cell Lung CancerSemantic proximity Read ↗

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity Read ↗

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancerSemantic proximity Read ↗

Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysisSemantic proximity Read ↗

Molecular phenotypes stratify small cell lung cancer for targeted therapy and immunotherapy.Semantic proximity Read ↗

Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung CarcinomaSemantic proximity Read ↗

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read ↗

Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor ProgressionSemantic proximity Read ↗

Spatial transcriptomics reveals macrophage domestication by epithelial cells promotes immunotherapy resistance in small cell lung cancerSemantic proximity Read ↗

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancerSemantic proximity Read ↗

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapySemantic proximity Read ↗

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.