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Article

Impact of Mechanical Strain and Nicotinamide on RUNX2-Deficient Osteoblast Mimicking Cleidocranial Dysplasia.

International journal of molecular sciences - 21 Nov 2023

Schröder Agnes, Örs Talia, Byeon Ye-Oun, Cieplik Fabian, Proff Peter, Kirschneck Christian, Paddenberg Eva

Abstract excerpt

Cleidocranial dysplasia (CCD) is a rare genetic defect caused by a heterozygous mutation of runt-related transcription factor 2 (RUNX2), which is important for osteoblast and skeletal development. RUNX2-deficiency causes extra- and intra-oral malformations that often require orthodontic treatment. Nicotinamide (NAM) affects bone remodelling processes. As these are crucial for orthodontic therapy, NAM could...

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Identifiers

PMID: 38068903
DOI: 10.3390/ijms242316581
PMCID: PMC10705976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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