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Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

16 Jan 2020

Abstract excerpt

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST), which inhibits osteoblasts, and expressing receptor activator of nuclear factor-κB ligand (RANKL/TNFSF11) which recruits osteoclasts. Both SOST and RANKL are...

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PMID: 32550554
DOI: 10.1016/j.gene.2020.100027

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