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Article

RUNX2 mutation reduces osteogenic differentiation of dental follicle cells in cleidocranial dysplasia.

Mutagenesis - 17 Sept 2018

Liu Yang, Wang Yixiang, Sun Xiangyu, Zhang Xianli, Wang Xiaozhe, Zhang Chenying, Zheng Shuguo

Abstract excerpt

Disturbed permanent tooth eruption is common in cleidocranial dysplasia (CCD), a skeletal disorder caused by heterozygous mutation of RUNX2, but the mechanism underlying is still unclear. As it is well known that dental follicle cells (DFCs) play a critical role in tooth eruption, the changed biological characteristics of DFCs might give rise to disturbance of permanent tooth eruption in CCD patients. Thus,...

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Source

Identifiers

PMID: 29947791
DOI: 10.1093/mutage/gey010

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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