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Article

Influence of Single-Nucleotide Polymorphisms on Vitamin D Receptor Expression in Periodontal Ligament Fibroblasts as a Response to Orthodontic Compression.

International journal of molecular sciences - 15 Dec 2022

Küchler Erika Calvano, Schröder Agnes, Spanier Gerrit, Thedei Geraldo, Carvalho Ribeiro de Oliveira Maria Beatriz, de Menezes-Oliveira Maria Angélica Hueb, Proff Peter, Kirschneck Christian

Abstract excerpt

This study aimed to evaluate if single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene are associated with gene expression in human periodontal ligament (hPDL) fibroblasts under simulated orthodontic compressive force. hPDL samples from 57 patients were used. A physiological compressive strain was performed to simulate orthodontic tooth movement in pressure areas under cell culture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36555589
DOI: 10.3390/ijms232415948
PMCID: PMC9787981

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