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Histone Deacetylase 7 Associates With Runx2 and Represses Its Activity During Osteoblast Maturation in a Deacetylation-Independent Manner

12 Nov 2007

Abstract excerpt

UNLABELLED: HDAC7 associates with Runx2 and represses Runx2 transcriptional activity in a deacetylase-independent manner. HDAC7 suppression accelerates osteoblast maturation. Thus, HDAC7 is a novel Runx2 co-repressor that regulates osteoblast differentiation. INTRODUCTION: Runx2 is a key regulator of gene expression in osteoblasts and can activate or repress transcription depending on interactions with various...

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PMID: 17997710
DOI: 10.1359/jbmr.071104

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