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Article

Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis.

Experimental biology and medicine (Maywood, N.J.) - 1 Nov 2023

Li Dan, Wang Dong, Johann Donald J, Hong Huixiao, Xu Joshua

Abstract excerpt

Tumor mutational burden (TMB), when at a high level, is an emerging indicative factor of sensitivity to immune checkpoint inhibitors. Previous studies have shown that the more affordable and accurate targeted panels can be used to measure TMB as a substitute for whole exome sequencing (WES). However, additional processes, such as hotspot mutations exclusion and TMB adjustment, are usually required to deal with...

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Identifiers

PMID: 38062992
DOI: 10.1177/15353702231211882
PMCID: PMC10798187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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