Article

Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-making

2022-06-16

Abstract excerpt

Tumor mutation burden (TMB) has been validated as a biomarker to predict the response of immune checkpoint inhibitors (ICIs) treatment in various cancers. However, the effects of different sequencing platforms, cancer types, and calculation algorithms on TMB as well as its cut-off value for predicting immunotherapy efficacy in the East Asian population still need to be further investigated. In this study, the data...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae3c75a0-c998-599a-8105-e970afe5cd65
DOI: 10.21203/rs.3.rs-1745663/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-makingDOI 10.21203/rs.3.rs-1745663/v1Read

Expert consensus on the detection and clinical application of tumor mutational burden.Semantic proximity Read

Estimating tumor mutational burden across multiple cancer types using whole-exome sequencingSemantic proximity Read

High tumor mutational burden predicts survival and responses to ICI immunotherapy in a cancer-dependent mannerSemantic proximity Read

Influence of low tumor content on tumor mutational burden estimation by whole-exome sequencing and targeted panel sequencing.Semantic proximity Read

Novel tumor mutation score versus tumor mutation burden in predicting survival after immunotherapy in pan-cancer patients from the MSK-IMPACT cohortSemantic proximity Read

Continuous prediction for tumor mutation burden based on transcriptional data in gastrointestinal cancers.Semantic proximity Read

Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis.Semantic proximity Read

Continuous Prediction for Tumor Mutation Burden Based on Transcriptional Data in Gastrointestinal CancersSemantic proximity Read

Assessment of tumor mutation burden calculation from gene panel sequencing dataSemantic proximity Read

Harmonizing tumor mutational burden analysis: Insights from a multicenter study using in silico reference data sets in clinical whole-exome sequencing (WES).Semantic proximity Read

Viewpoint: The Current Advances and Future Optimization of Blood-based Tumor Mutation Burden as a Biomarker for Cancer ImmunotherapySemantic proximity Read

A novel tumor mutational burden estimation model as a predictive and prognostic biomarker in NSCLC patients.Semantic proximity Read