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Size matters: Dissecting key parameters for panel‐based tumor mutational burden analysis

22 Sept 2018

Abstract excerpt

Tumor mutational burden (TMB) represents a new determinant of clinical benefit from immune checkpoint blockade that identifies responders independent of PD-L1 expression levels and is currently being explored in clinical trials. Although TMB can be measured directly by comprehensive genomic approaches such as whole-genome and exome sequencing, broad availability, short turnaround times, costs and amenability to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30238975
DOI: 10.1002/ijc.31878

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