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Article

Leveraging non-coding regions to guarantee the accuracy of small-sized panel-based tumor mutational burden estimates.

Cancer science - 1 Dec 2024

Nishino Takahiro, Yumura Mio, Sunami Kuniko, Kubo Takashi, Ichikawa Hitoshi, Yasuda Tomoyo, Furukawa Eisaku, Nagai Momoko, Yatabe Yasushi, Kato Mamoru, Kohno Takashi

Abstract excerpt

Accurate estimation of tumor mutational burden (TMB) as a predictor of responsiveness to immune checkpoint inhibitors in gene panel assays requires an adequate panel size. The current calculations of TMB only consider coding regions, while most of gene panel assays interrogate non-coding regions. Leveraging the non-coding regions is a potential solution to address this panel size limitation. However, the impact...

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PMID: 39351646
DOI: 10.1111/cas.16342
PMCID: PMC11611766

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