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Article

Quantifying potential confounders of panel-based tumor mutational burden (TMB) measurement.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2020

Budczies Jan, Kazdal Daniel, Allgäuer Michael, Christopoulos Petros, Rempel Eugen, Pfarr Nicole, Weichert Wilko, Fröhling Stefan, Thomas Michael, Peters Solange, Endris Volker, Schirmacher Peter, Stenzinger Albrecht

Abstract excerpt

OBJECTIVES: Retrospective data including subgroup analyses in clinical studies have sparked strong interest in developing tumor mutational burden (TMB) as a predictive biomarker for immune checkpoint blockade. While individual factors influencing panel sequencing based measurement of TMB (psTMB) have been discussed in the recent literature, an integrative study quantifying, comparing and combining all potential...

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PMID: 32143116
DOI: 10.1016/j.lungcan.2020.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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