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Tumor mutational burden quantification from targeted gene panels: major advancements and challenges

15 Jul 2019

Abstract excerpt

Tumor mutational burden (TMB), the total number of somatic coding mutations in a tumor, is emerging as a promising biomarker for immunotherapy response in cancer patients. TMB can be quantitated by a number of NGS-based sequencing technologies. Whole Exome Sequencing (WES) allows comprehensive measurement of TMB and is considered the gold standard. However, to date WES remains confined to research settings, due...

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PMID: 31307554
DOI: 10.1186/s40425-019-0647-4

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