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Article

Harmonizing tumor mutational burden analysis: Insights from a multicenter study using in silico reference data sets in clinical whole-exome sequencing (WES).

American journal of clinical pathology - 3 Oct 2024

Yu Lijia, Zhang Yuanfeng, Wang Duo, Li Lin, Zhang Rui, Li Jinming

Abstract excerpt

OBJECTIVES: Tumor mutational burden (TMB) is a significant biomarker for predicting immune checkpoint inhibitor response, but the clinical performance of whole-exome sequencing (WES)-based TMB estimation has received less attention compared to panel-based methods. This study aimed to assess the reliability and comparability of WES-based TMB analysis among laboratories under routine testing conditions. METHODS: A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38733635
DOI: 10.1093/ajcp/aqae056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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