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Article

Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice.

JCI insight - 23 Jan 2024

Li Yiran, Han Mingyuan, Singh Shilpi, Breckenridge Haley A, Kreger Jordan E, Stroupe Claudia C, Sawicky Daniel A, Kuo Shiuhyang, Goldsmith Adam M, Ke Fang, Shenoy Anukul T, Bentley J Kelley, Matsumoto Ichiro, Hershenson Marc B

Abstract excerpt

Infection of immature mice with rhinovirus (RV) induces an asthma-like phenotype consisting of type 2 inflammation, mucous metaplasia, eosinophilic inflammation, and airway hyperresponsiveness that is dependent on IL-25 and type 2 innate lymphoid cells (ILC2s). Doublecortin-like kinase 1-positive (DCLK1+) tuft cells are a major source of IL-25. We sought to determine the requirement of tuft cells for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38061015
DOI: 10.1172/jci.insight.166136
PMCID: PMC10906234

Genes

DCLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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