Article
Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2016
Huang C, Jiang D, Francisco D, Berman R, Wu Q, Ledford J G, Moore C M, Ito Y, Stevenson C, Munson D, Li L, Kraft M, Chu H W
Abstract excerpt
BACKGROUND: Rhinovirus (RV) infection in asthma induces varying degrees of airway inflammation (e.g. neutrophils), but the underlying mechanisms remain unclear. OBJECTIVE: The major goal was to determine the role of genetic variation [e.g. single nucleotide polymorphisms (SNPs)] of Toll-interacting protein (Tollip) in airway epithelial responses to RV in a type 2 cytokine milieu. METHODS: DNA from blood of...
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