Article
Epithelial cell responses to rhinovirus identify an early-life-onset asthma phenotype in adults.
The Journal of allergy and clinical immunology - 1 Sept 2022
Chang Eugene H, Pouladi Nima, Guerra Stefano, Jandova Jana, Kim Alexander, Li Haiquan, Li Jianrong, Morgan Wayne, Stern Debra A, Willis Amanda L, Lussier Yves A, Martinez Fernando D
Abstract excerpt
BACKGROUND: The study of pathogenic mechanisms in adult asthma is often marred by a lack of precise information about the natural history of the disease. Children who have persistent wheezing (PW) during the first 6 years of life and whose symptoms start before age 3 years (PW+) are much more likely to have wheezing illnesses due to rhinovirus (RV) in infancy and to have asthma into adult life than are those who...
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