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Article

Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype.

The Journal of allergy and clinical immunology - 1 Sept 2020

Rajput Charu, Han Mingyuan, Ishikawa Tomoko, Lei Jing, Jazaeri Seyedehzarifeh, Bentley J Kelley, Hershenson Marc B

Abstract excerpt

BACKGROUND: Early-life wheezing-associated respiratory tract infection by rhinovirus (RV) is a risk factor for asthma development. Infants are infected with many different RV strains per year. OBJECTIVE: We previously showed that RV infection of 6-day-old BALB/c mice induces a mucous metaplasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s). We hypothesized that early-life RV infection alters...

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Identifiers

PMID: 32344055
DOI: 10.1016/j.jaci.2020.03.039
PMCID: PMC8097639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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