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Article

Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice.

Mucosal immunology - 1 Nov 2021

Han Mingyuan, Ishikawa Tomoko, Stroupe Claudia C, Breckenridge Haley A, Bentley J Kelley, Hershenson Marc B

Abstract excerpt

Compared to other RV species, RV-C has been associated with more severe respiratory illness and is more likely to occur in children with a history of asthma or who develop asthma. We therefore inoculated 6-day-old mice with sham, RV-A1B, or RV-C15. Inflammasome priming and activation were assessed, and selected mice treated with recombinant IL-1β. Compared to RV-A1B infection, RV-C15 infection induced an...

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Source

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Identifiers

PMID: 34354243
DOI: 10.1038/s41385-021-00436-0
PMCID: PMC8542611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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