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Article

Evolution of Escherichia coli strains under competent or compromised adaptive immunity.

PLoS pathogens - 1 Apr 2025

Ameline Camille, Seixas Elsa, Barreto Hugo C, Frazão Nelson, Rodrigues Miguel V, Ventura M Rita, Lourenço Marta, Gordo Isabel

Abstract excerpt

Escherichia coli is a commensal of the intestine of most mammals, but also an important human pathogen. Within a healthy human its population structure is highly dynamic, where typically a dominant E. coli strain is accompanied by several low abundance satellite strains. However, the factors underlying E. coli strain dynamics and evolution within hosts are still poorly understood. Here, we colonised germ-free...

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Topics

Animals
Adaptive Immunity
Escherichia coli
Mice
Mice, Knockout
Escherichia coli Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice, Inbred C57BL

Biological Evolution

Evolution, Molecular

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40273038
DOI: 10.1371/journal.ppat.1012442
PMCID: PMC12021133

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