Article

Dysbiosis personalizes fitness effect of antibiotic resistance in the mammalian gut

2019-08-28

Abstract excerpt

<h4>SUMMARY</h4> The fitness cost of antibiotic resistance in the absence of antibiotics is crucial to the success of suspending antibiotics as a strategy to lower resistance. Here we show that after antibiotic treatment the cost of resistance within the complex ecosystem of the mammalian gut is personalized. Using mice as an in vivo model, we find that the fitness effect of the same resistant mutation can be de...

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Literature Corpus work: d539381a-302e-59a1-aaf9-40068f45057e
DOI: 10.1101/748897

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