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Article

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases.

Cell host & microbe - 10 Jul 2024

Kumbhari Adarsh, Cheng Thomas N H, Ananthakrishnan Ashwin N, Kochar Bharati, Burke Kristin E, Shannon Kevin, Lau Helena, Xavier Ramnik J, Smillie Christopher S

Abstract excerpt

Gut bacteria are implicated in inflammatory bowel disease (IBD), but the strains driving these associations are unknown. Large-scale studies of microbiome evolution could reveal the imprint of disease on gut bacteria, thus pinpointing the strains and genes that may underlie inflammation. Here, we use stool metagenomes of thousands of IBD patients and healthy controls to reconstruct 140,000 strain genotypes,...

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Identifiers

PMID: 38917808
DOI: 10.1016/j.chom.2024.05.022
PMCID: PMC11239293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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